Otumfuo Osei Tutu II born Nana Barima Kwaku Duah on 6 May 1950 is the 16th Asantehene, enstooled on 26 April 1999. By name, Otumfuo Osei Tutu II is in direct succession to the 17th-century co-founder of the Ashanti Empire, Otumfuo Osei Tutu I.

He is the Life Patron of the Royal Golf Club, Kumasi and also the Chancellor of the Kwame Nkrumah University of Science and Technology (KNUST). Otumfuo Osei Tutu II is the Grand Patron of the Grand Lodge of Ghana and the Sword Bearer of the United Grand Lodge of England.

Nana Barima Kwaku Duah was the third son and youngest of the five children (three sons and two daughters) of Nana Afia Kobi Serwaa Ampem II, Asantehemaa (Queen-mother of the Ashanti). His father Nana Kwame Boakye-Dankwa was from Kantinkyere in Ashanti and was also the Brehyia Duke of Asante. Nana Kwame Boakye-Dankwa died on 1 January 2002, in Kumasi, Ashanti.

Otumfuo Osei Tutu was named after his paternal grandfather, Ohenenana Kwaku Duah (Nana Agari), Brahyiahene, of Kantinkyiren in the Atwima district.His siblings include Nana Ama Konadu, the 14th Asanteheemaa as well as the late Nana Konadu Yiadom III Barima Kwabena Poku, Barima Akwasi Prempeh. When he was about five years old, Otumfuo moved into the royal household of his uncle, Oheneba Mensah Bonsu, the Hiahene, enstooled in 1952, as early preparation for his future role.

Osei Tutu has six children. His father had other offspring from other marriages, including Yaw Boateng, Kwaku Duah, Kwabena Agyei-Bohyen, Afua Sarpong, and Ama Agyemang (Kumasi, Ashanti), Fredua Agyeman Prempeh, Nana Kwasi Agyemang Prempeh, and Nana Kwasi Boachie Gyambibi (Kumasi, Ashanti).

He had his elementary education in Kumasi and in 1964, went on to the Sefwi Wiaso Secondary School where he obtained his 'O' Level was taught by the late Omanhene of Sefwi Wiawso, Nana Kwadwo Aduhene II who was a cousin of Otumfuo's guardian uncle, Oheneba Mensah Bonsu, Hiahene. He also attended the Osei Kyeretwie Secondary School (OKESS).

He studied accountancy studies at the erstwhile Institute of Professional Studies, which is today known as the University of Professional Studies in Accra. He then enrolled at the London Meteropolitan University where he earned a degree in Human Resources Management and Public Administration. He was awarded an honorary doctorate, at a ceremony at the Barbican Centre on 11 January 2006.

Between 1981 and 1985, he was a senior consultant at the Mutual of Omaha Insurance Company in Toronto, Canada. He returned to London in 1985 and became the Personnel Manager at the Manpower Services Commission of the Brent Council. He then founded his own mortgage finance firm, Primoda Financial Services Limited, located on Kilburn High Road, North West London.He returned to his native Ghana in 1989 to start a transport business, the Transpomech International (Ghana) Limited.

The Asantehene is highly revered in the Asante territories (Ashanti Region and other parts of Ghana) and is often regarded as the first among equals of traditional rulers in Ghana. Otumfuo Osei Tutu II has frequently commented on the work of Ghanaian politicians.

John Agyekum Kufuor instituted the Committee of Eminent Chiefs headed by Osei Tutu II to intervene in the 2002 Dagbon chieftaincy crisis. The committees' mandate included facilitating negotiation and mediation talks between the Andani and Abudu royal families, and drawing a roadmap for the restoration of peace in the Kingdom of Dagbon. The committee presented its recommendation to the Government of Ghana on November 21, 2018.The government implemented the recommendations that included the performance of the funerals of Mahamadu IV and Yakubu II from December 14, 2018, to January 18, 2019. These were then followed by the investiture of Bukali II as substantive regent of the Kingdom of Dagbon. In December 2019, Bukali II paid a courtesy call on Otumfour Osei Tutu at the Manhyia Palace, to express his gratitude for the role the Asante king played in the peace process.

Osei Tutu II's 20th-anniversary commemoration took place on the 21st of April 2019, at the Dwabirem of the Manhyia Palace. This was at the grand durbar of the Akwasidaekese. Dignitaries like Nana Addo Dankwa Akufo-Addo, Michael Ashwin Satyandre Adhin the vice president of Suriname, and Torgbui Sri, the Awomefia of the Anlo state were in attendance. Other dignitaries included Diplomats and royals from Namibia, Kuwait, Germany, China, Morocco, Latvia, Botswana, and Palestine.

In July 2019, Otumfuo Osei Tutu II announced his devotion to protecting the water bodies of the Asante Kingdom. This would involve the planting of 2.5 million trees around Lake Bosomtwe and would cover 400 hectares. This would aid in improving the ecosystem, cushion climate change and enhance environmental awareness among the communities around the lake.The tree planting initiative is a collaboration between the Oheneba Poku Foundation and Manhyia Palace. The Forestry Commission, the Environmental Protection Agency (EPA), the Water Resources Commission, the Ghana Tourism Authority, UNESCO, the District Assemblies of Become-Freho and Bosumtwe, and the Lake Bosomtwe Community Resources Management Areas (CREMA), which is an NGO are the other stakeholders.